We systematically review the impact of polyurethane insulation and polyurethane household products on the indoor environmental quality of buildings. The review breaks down polyurethane products into constituent compounds (isocyanate, polyol, flame retardant, blowing agent and catalyst) as well as secondary emissions, and discusses their implications on human health. Concentrations of compounds emitted from insulation, and household materials, measured in laboratory experiments and case studies are presented in the context of the built environment.